Table 1.
Clinical Characteristics of the Included Population
| Clinical Variables | Overall (N=1789) | Patients With Thrombocytopenia (n=495) | Patients Without Thrombocytopenia (n=1294) | P Value |
|---|---|---|---|---|
| Age, y | 57.6±5.7 | 58.4±5.8 | 57.3±5.6 | <0.001 |
| Male sex | 585 (32.7) | 212 (42.8) | 373 (28.8) | <0.001 |
| Previous diabetes mellitus | 106 (5.9) | 28 (5.7) | 78 (6.0) | 0.766 |
| Previous AFa | 1129 (63.1) | 334 (67.5) | 795 (61.4) | 0.018 |
| NYHA class >II | 796 (44.5) | 248 (50.1) | 548 (42.3) | 0.003 |
| ALT, U/L | 21.0 (16.0–28.0) | 20.0 (16.0–27.0) | 21.0 (16.8–28.0) | 0.180 |
| Total bilirubin, μmol/L | 19.1 (14.3–25.4) | 22.1 (17.0–30.2) | 17.8 (13.7–23.7) | <0.001 |
| Hemoglobin, g/L | 134.4±15.7 | 133.5±15.7 | 134.8±15.8 | 0.125 |
| Serum creatinine, μmol/L | 80.4±21.6 | 84.0±23.9 | 79.1±20.6 | <0.001 |
| Platelet counts, ×109/L | 183.9±56.5 | 121.5±21.1 | 207.8±46.7 | <0.001 |
| LA thrombus | 294 (16.4) | 81 (16.4) | 213 (16.5) | 0.961 |
| LVEF, % | 61.6±9.2 | 61.1±9.0 | 61.7±9.3 | 0.208 |
| Multivalvular heart disease | 1518 (84.9) | 444 (89.1) | 1077 (83.2) | 0.002 |
| RV diameter, mm | 51.7±7.1 | 53.4±7.9 | 51.1±6.7 | <0.001 |
| Valve surgery | ||||
| AVR | 750 (41.9) | 218 (44.0) | 532 (41.1) | 0.262 |
| MVR | 1704 (95.2) | 470 (94.9) | 1234 (95.4) | 0.713 |
| TVI | 1395 (78.0) | 416 (84.0) | 979 (75.7) | <0.001 |
| AVR+MVR | 670 (37.5) | 196 (39.6) | 474 (36.6) | 0.246 |
| AVR+MVR+TVI | 542 (30.3) | 168 (33.9) | 374 (28.9) | 0.038 |
| CABG surgery | 82 (4.6) | 15 (3.0) | 67 (5.2) | 0.052 |
| Transfusion | ||||
| ≥1 U platelets in hospital | 302 (16.9) | 152 (30.7) | 150 (11.6) | <0.001 |
| ≥1 U RBCs in hospital | 1377 (77.0) | 369 (74.5) | 1008 (77.9) | 0.132 |
| ≥5 U RBCs in hospital | 643 (35.9) | 202 (40.8) | 441 (34.1) | 0.008 |
| Hospital stay, d | 23.9±11.9 | 25.3±13.5 | 23.4±11.1 | 0.004 |
| Postoperative events | ||||
| AKI | 1014 (56.7) | 298 (61.1) | 716 (56.6) | 0.090 |
| Dialysis | 43 (2.4) | 23 (4.6) | 20 (1.5) | <0.001 |
| Rethoracotomy for hemostasis | 81 (4.5) | 38 (7.7) | 43 (3.3) | <0.001 |
| Stroke | 25 (1.4) | 8 (1.6) | 17 (1.3) | 0.626 |
| In‐hospital all‐cause death | 69 (3.9) | 34 (6.9) | 35 (2.7) | <0.001 |
Data are given as mean±SD, number (percentage), or median (first‐third quartile). AF indicates atrial fibrillation; AKI, acute kidney injury; ALT, alanine transaminase; AVR, aortic valve replacement; CABG, coronary artery bypass grafting; LA, left atrial; LVEF, left ventricular ejection fraction; MVR, mitral valve replacement; NYHA, New York Heart Association; RBC, red blood cell; RV, right ventricular; and TVI, tricuspid valve intervention.
a
Patients with AF in medical history and hospital admission physical examination findings.