Table 1.
Baseline Characteristics of Study Population, by APOL1 Risk Status
| Characteristic | APOL1 Low‐Risk (n=1533) | APOL1 High‐Risk (n=213) |
|---|---|---|
| Age, y | 62±10 | 62±10 |
| Women | 847 (55) | 105 (49) |
| Education | ||
| Less than high school | 171 (11) | 32 (15) |
| High school graduate | 304 (20) | 38 (18) |
| Post‐secondary education | 1045 (69) | 142 (67) |
| Employment | ||
| Employed | 610 (40) | 83 (39) |
| Unemployed/employed part‐time | 114 (8) | 22 (10%) |
| Retired/homemaker | 795 (52) | 107 (51) |
| Annual family income | ||
| <$25 000 | 429 (30) | 59 (30) |
| $25 000 to $49 999 | 462 (33) | 61 (31) |
| $50 000 to $74 999 | 276 (20) | 39 (20) |
| ≥$75 000 | 247 (18) | 35 (18) |
| Smoking status | ||
| Never | 692 (46) | 99 (47) |
| Former | 545 (36) | 72 (34) |
| Current | 274 (18) | 41 (19) |
| Body mass index, kg/m2 | 30.2±5.9 | 30.0±5.9 |
| Diabetes mellitus | 257 (17) | 46 (22) |
| Fasting glucose, mg/dL | 100±32 | 102±33 |
| Hypertension | 897 (59) | 134 (63) |
| Systolic BP, mm Hg | 132±22 | 131±21 |
| Diastolic BP, mm Hg | 74±11 | 75±10 |
| Use of antihypertensive medications | 757 (49) | 116 (55) |
| Total cholesterol, mg/dL | 190±36 | 190±37 |
| LDL, mg/dL | 117±33 | 115±34 |
| HDL, mg/dL | 52±15 | 54±16 |
| Triglyceride, mg/dL | 90 [66–123] | 88 [67–122] |
| Use of lipid‐lowering medications | 237 (16) | 39 (18) |
| Moderate‐vigorous PA (MET, min/wk) | 4560 [2110–8640] | 4560 [2258–8505] |
| Family history of heart disease, No. (%) | 612 (43) | 70 (34) |
| eGFRCysC, mL/min per 1.73 m2 | 89±20 | 89±20 |
| UACR, mg/g | 5.4 [3.1–12.5] | 6.2 [3.5–15.6] |
| UACR ≥30 mg/g | 169 (11) | 33 (16) |
Values are presented as mean±SD, median [interquartile range], or number (percentage). APOL1 high‐risk defined as 2 risk alleles and low‐risk defined as 0 or 1 risk allele. BP indicates blood pressure; eGFRCysC, cystatin C–based estimated glomerular filtration rate; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; MET, metabolic equivalent; PA, physical activity; UACR, urine albumin to creatinine ratio.