Table 3.
Association of APOL1 Risk Variants With Incident Cardiovascular Disease Events in MESA
| No. | Rate | Model 1 | Model 2 | |
|---|---|---|---|---|
| % Per Year | HR (95% CI) | HR (95% CI) | ||
| Incident CHD (composite) | ||||
| APOL1 low‐risk | 1532 | 0.7 | 1.00 (reference) | 1.00 (reference) |
| APOL1 high‐risk | 213 | 0.7 | 0.97 (0.54–1.73) | 0.99 (0.55–1.78) |
| Incident MI | ||||
| APOL1 low‐risk | 1532 | 0.2 | 1.00 (reference) | 1.00 (reference) |
| APOL1 high‐risk | 213 | 0.3 | 1.24 (0.52–2.94) | 1.23 (0.51–2.96) |
| Incident stroke | ||||
| APOL1 low‐risk | 1532 | 0.3 | 1.00 (reference) | 1.00 (reference) |
| APOL1 high‐risk | 213 | 0.4 | 1.00 (0.45–2.20) | 1.02 (0.46–2.25) |
Coronary heart disease (CHD) defined by myocardial infarction (MI), definite or probable angina (if followed by revascularization), resuscitated cardiovascular arrest, and CHD death. APOL1 high‐risk defined as 2 risk alleles and low‐risk defined as 0 or 1 risk allele. Model 1: unadjusted; model 2: adjusted for age, sex, and African ancestry. CI indicates confidence interval; HR, hazard ratio; MESA, Multi‐Ethnic Study of Atherosclerosis.