Table 1.
Baseline Characteristics of the Study Cohort (ARIC Study Visit 4 1996–1998)a
| Characteristic | Lp(a) Categories, mg/dL | P Valueb | ||||
|---|---|---|---|---|---|---|
| ≤10 | >10 to 20 | >20 to 30 | >30 to 50 | >50 | ||
| No. | 4229 | 1732 | 887 | 1177 | 1883 | |
| Age, y | 62.8 (5.7) | 62.8 (5.5) | 62.6 (5.7) | 62.6 (5.7) | 62.5 (5.6) | 0.3 |
| Men, No. (%) | 1999 (47.3) | 772 (44.6) | 373 (42.1) | 500 (42.5) | 702 (37.3) | <0.001 |
| Black, No. (%) | 284 (6.7) | 338 (19.5) | 357 (40.2) | 524 (44.5) | 633 (33.6) | <0.001 |
| Current smoking, No. (%) | 604 (14.3) | 274 (15.8) | 140 (15.8) | 162 (13.8) | 287 (15.2) | <0.001 |
| SBP, mm Hg | 126.0 (18.1) | 126.7 (19.0) | 128.7 (18.6) | 129.8 (20.0) | 127.8 (19.4) | <0.001 |
| DBP, mm Hg | 70.2 (9.8) | 71.0 (10.2) | 71.9 (10.5) | 72.3 (10.7) | 71.3 (10.8) | <0.001 |
| Hypertension, No. (%) | 1765 (41.9) | 752 (43.5) | 446 (50.5) | 635 (54.1) | 907 (48.3) | <0.001 |
| Treatment for hypertension, No. (%) | 1598 (37.8) | 651 (37.6) | 380 (42.8) | 572 (48.6) | 855 (45.4) | <0.001 |
| Heart rate, beats per min | 62.5 (9.6) | 62.5 (9.8) | 63.1 (10.0) | 63.2 (10.7) | 62.8 (9.8) | 0.16 |
| Height, cm | 167.9 (9.5) | 167.8 (9.4) | 167.4 (9.4) | 167.7 (8.9) | 167.0 (9.0) | 0.01 |
| BMI, kg/m2 | 28.4 (5.2) | 28.4 (5.4) | 29.0 (5.8) | 29.2 (5.7) | 28.8 (5.8) | <0.001 |
| ECG LVH, No. (%) | 120 (2.8) | 62 (3.6) | 45 (5.1) | 68 (5.8) | 87 (4.6) | <0.001 |
| PR interval, ms | 166.3 (26.1) | 165.5 (25.7) | 168.1 (27.0) | 168.4 (27.5) | 167.5 (26.9) | 0.01 |
| LDL‐C, mg/dL | 117.3 (32.0) | 123.2 (32.4) | 124.9 (35.1) | 125.3 (34.7) | 132.6 (32.6) | <0.001 |
| HDL‐C, mg/dL | 49.3 (16.6) | 49.7 (15.3) | 51.3 (16.3) | 51.4 (16.7) | 52.6 (16.8) | <0.001 |
| Triglycerides, mg/dL | 146.5 (72.3) | 132.1 (62.4) | 125.7 (59.2) | 127.8 (62.6) | 129.0 (61.0) | <0.001 |
| Pro‐NT‐BNP, pg/mLc | 65.0 (33.4–123.8) | 64.1 (30.0–120.5) | 60.4 (28.3–122.6) | 67.0 (33.1–127.3) | 65.0 (33.4–123.8) | <0.001 |
| Lipid‐lowering medications, No. (%) | 577 (13.6) | 213 (12.3) | 98 (11.0) | 156 (13.3) | 334 (17.7) | <0.001 |
| Prevalent CHF, No. (%) | 47 (1.1) | 24 (1.4) | 18 (2.0) | 21 (1.8) | 38 (2.0) | 0.04 |
| Diabetes mellitus, No. (%) | 623 (14.7) | 215 (12.4) | 138 (15.6) | 228 (19.4) | 306 (16.3) | <0.001 |
| Ischemic stroke, No. (%) | 217 (5.1) | 107 (6.2) | 54 (6.1) | 96 (8.2) | 140 (7.4) | <0.001 |
| CHD, No. (%) | 307 (7.3) | 110 (6.4) | 61 (6.9) | 79 (6.7) | 185 (9.8) | <0.001 |
| CHA2DS2‐VASc | 1.7 (1.2) | 1.8 (1.2) | 1.9 (1.2) | 2.0 (1.3) | 1.9 (1.3) | <0.001 |
ARIC indicates Atherosclerosis Risk in Communities; BMI, body mass index; CHD, coronary heart disease; CHF, congestive heart failure; DBP, diastolic blood pressure; HDL‐C, high‐density lipoprotein cholesterol; LVH, left ventricular hypertrophy; LDL‐C, low‐density lipoprotein cholesterol; LP(a), lipoprotein(a); pro–NT‐BNP, N‐terminal pro–B type natriuretic peptide; SBP, systolic blood pressure.
a
Data are expressed as mean (SD) or number (percentage) unless otherwise indicated.
b
P values were obtained with ANOVA for continuous variables and chi‐square test for categorical variables.
c
Median (interquartile range).