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. 2017 Dec 8;6(12):e007622. doi: 10.1161/JAHA.117.007622

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Structural remodeling of the lateral membrane of transverse aortic constriction (TAC) cardiomyocytes. A, Typical scanning ion conductance microscopy (SICM) scan and topology profile along the dashed line of a sham–operated on (Sham) cardiomyocyte lateral membrane (arrows indicate T‐tubule openings). B, Typical SICM scan and topology profile along the dashed line of a TAC cardiomyocyte lateral membrane. C, Unchanged crest‐crest distance between Sham and TAC. D, Decreased Z‐groove ratio in TAC compared with Sham.