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. 2017 Dec 8;6(12):e007622. doi: 10.1161/JAHA.117.007622

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Decreased sodium current (I_Na) at the crest of transverse aortic constriction (TAC) cardiomyocytes. A, Typical I_Na recordings at the crest of sham–operated on (Sham) and TAC lateral membrane. Brackets highlight single‐channel events. B, Typical I_Na recordings in the groove/T tubule of Sham and TAC lateral membrane. Brackets highlight single‐channel events. Please note the scale. C, Identical unitary channel conductance in crest in Sham and TAC. Numbers of events at −50, −60, −70, and −80 mV are for Sham 68, 138, 139, and 85, respectively, and for TAC 29, 58, 87, and 114, respectively. D, Identical unitary channel conductance in groove/T tubule in Sham and TAC. Numbers of events at −50, −60, −70, and −80 mV are for Sham 73, 76, 62, and 72, respectively, and for TAC 66, 67, 58, and 66, respectively. E, Decreased numbers of channels at the crest of TAC cardiomyocytes when compared with TAC (χ² test, P=0.012 for “0”). F, Identical number of open channels in groove/T tubule in Sham and TAC cardiomyocytes.