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. 2017 Dec 8;6(12):e007622. doi: 10.1161/JAHA.117.007622

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Increased late opening of sodium channels at the crest of transverse aortic constriction (TAC) cardiomyocytes. A, Typical recordings showing late sodium channel openings in sham–operated on (Sham) and TAC crests. Magnification of the rectangular red boxes is shown below. B, Typical recordings showing late sodium channel openings in Sham and TAC groove/T tubule. Magnification of the rectangular red boxes is shown below. C, Increased number of late openings in TAC crest compared with Sham crest. D, Identical number of late openings in Sham and TAC groove/T tubule.