TABLE 1.
Plasma fractional transfer coefficients in control and VA- and VARA-supplemented neonatal rat pups dosed orally with [3H]retinol on postnatal day 41
| Fractional transfer coefficients [L(I,J)] | |||
|---|---|---|---|
| Variable | Control group | VA group | VARA group |
| Transit of retinol through digestive system | 26.9 ± 2.0a | 31.9 ± 13.4a,b | 11.5 ± 1.2b |
| Uptake of CM-REs from plasma to organs | 567 ± 95.2 | 508 ± 135 | 647 ± 105 |
| Release of RBP-ROH from liver to plasma | 2.5 ± 0.1a | 4.0 ± 0.2b | 5.5 ± 0.1c |
| Uptake of RBP-ROH from plasma to organs | 29.8 ± 0.8a | 245 ± 184a,b | 169.4 ± 3.2b |
| Recycling of RBP-ROH from organs to plasma | 0.3 ± 0.0a | 1.2 ± 0.1b | 0.8 ± 0.0c |
| Irreversible loss of retinol from organs | 0.06 ± 0.00a | 0.01 ± 0.01b | 0.01 ± 0.00b |
1
Values are means ± SEMs. Means within a row without a common superscript letter differ, P < 0.05 (ANOVA). CM-RE, chylomicron retinyl ester; RBP-ROH, retinol-binding protein–bound retinol; VA, vitamin A; VARA, vitamin A combined with retinoic acid.