TABLE 3.
Fractional uptakes of CM-REs and RBP-ROH from plasma to organs in control and VA- and VARA-supplemented neonatal rat pups dosed orally with [3H]retinol on postnatal day 41
| Fractional transfer coefficients [L(I,J)], fraction of plasma retinol transferred/d | ||||||
|---|---|---|---|---|---|---|
| Uptake of CM-REs | Uptake of RBP-ROH | |||||
| Organ | Control group | VA group | VARA group | Control group | VA group | VARA group |
| Stomach2 | — | — | — | 2.0 ± 0.9 | 10.0 ± 5.5 | 0.6 ± 0.3 |
| Intestines | 39.3 ± 8.4a | 19.1 ± 3.1b | 327 ± 15.5c | 0.01 ± 0.01a | 0.04 ± 0.01b | 9.8 ± 0.3c |
| Liver | 77.3 ± 3.4a | 304 ± 15.6b | 223 ± 3.7c | 6.7 ± 1.0a | 17.0 ± 0.5b | 28.1 ± 1.0c |
| Lungs | 5.1 ± 0.2a | 15.0 ± 1.1b | 32.6 ± 0.3c | 0.2 ± 0.1a | 4.6 ± 0.4b | 0.1 ± 0.0a |
| Kidneys | 34.8 ± 1.6a | 4.9 ± 0.4b | 1.4 ± 0.1c | 3.2 ± 0.1a | 6.8 ± 0.5b | 3.0 ± 0.1a |
| Carcass | 271.6 ± 12.7a | 176 ± 11.7b | 438 ± 6.3c | 7.7 ± 0.1a | 196 ± 6.5b | 7.2 ± 0.1c |
1
Values are means ± SEMs. Means within a row without a common superscript letter differ, P < 0.05 (ANOVA). CM-RE, chylomicron retinyl ester; RBP-ROH, retinol-binding protein–bound retinol; VA, vitamin A; VARA, vitamin A combined with retinoic acid.
2
The stomach model did not include a CM-RE uptake component.