Table 1.
Top Nine Gene Ontology Pathways (GO: Biological Processes)
| Pathway | Total | Expected | Hits | P Value | FDR |
|---|---|---|---|---|---|
| Cell division | 509 | 54.6 | 95 | 3.83E-08 | 3.14E-05 |
| Mitotic cell cycle | 683 | 73.2 | 118 | 7.90E-08 | 3.24E-05 |
| Regulation of lipid metabolic process | 232 | 24.9 | 52 | 1.67E-07 | 4.57E-05 |
| Steroid metabolic process | 342 | 36.7 | 68 | 3.13E-07 | 5.47E-05 |
| Steroid biosynthetic process | 164 | 17.6 | 40 | 4.39E-07 | 5.47E-05 |
| Mitosis | 366 | 39.2 | 71 | 4.60E-07 | 5.47E-05 |
| Lipid biosynthetic process | 587 | 62.9 | 102 | 4.67E-07 | 5.47E-05 |
| Female gamete generation | 94 | 10.1 | 27 | 1.13E-06 | 0.000108 |
| M phase of mitotic cell cycle | 382 | 40.9 | 72 | 1.18E-06 | 0.000108 |
Top nine gene ontology pathways enriched among all differentially regulated genes in the granulosa cells of mice with depletion of Nr5a2 in granulosa cells (cKO mice) relative to CON mice, as revealed by microarray and Panther bioinformatic analyses.