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. 2017 Dec 14;4(6):ENEURO.0404-17.2017. doi: 10.1523/ENEURO.0404-17.2017

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Copyright © 2017 Edmond et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 1. — Top2β is expressed at high levels in postmitotic MNs. A, B, Low Top2β expression in MN progenitors (olig2+) at e11.5 (A) as compared to the lateral spinal cord where postmitotic MNs are located (B). C–E, Top2β is upregulated in postmitotic MNs at brachial levels at e11.5 (C), continues to be expressed as MNs navigate to their targets (e12.5; D) and high levels of expression are maintained until later stages of MN development (e14.5; E). F, Top2β expression in MNs at e12.5 at thoracic spinal cord levels. Scale bar = 50 μm.