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. 2017 Dec 14;4(6):ENEURO.0404-17.2017. doi: 10.1523/ENEURO.0404-17.2017

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Copyright © 2017 Edmond et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — Erosion of PMC identity in Top2β-/- mice. A, Scip and Isl1/2 expression in the cervical spinal cord in control and Top2β-/- mice at various time points during development. Scale bar = 50 μm. B, C, Quantitation of Scip-expressing MNs (B) and Scip protein levels (C) in the cervical spinal cord in control and Top2β-/- mice (see Materials and Methods for quantitation methods). D–F, Expression of PMC-specific genes ALCAM (D), pcdh10 (E), and PTN (F) is abolished in Top2β-/- embryos at e12.5.