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. 2017 Dec 14;4(6):ENEURO.0404-17.2017. doi: 10.1523/ENEURO.0404-17.2017

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Copyright © 2017 Edmond et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Defects in PGC columnar identities and peripheral projections in Top2β-/- mice. A, Organization of motor columns at thoracic levels of the spinal cord; PGC, preganglionic motor column, MMC, medial motor column, HMC, hypaxial motor column. B, C, Expression of PGC markers FoxP1 (white circle; B) and nNOS (C) is dramatically reduced in Top2β-/- embryos. The remaining neurons expressing nNOS are displaced ventrally. Scale bar = 50 μm. D, PGC neurons project to scg in Top2β-/-mice but show an aberrant innervation pattern at the target. scg: sympathetic chain ganglia and drg: dorsal root ganglia. Scale bar = 50 μm.