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Reduction of Hox protein levels in Top2β-/- mice. A–D, The rostrocaudal expression pattern of Hox genes is preserved in Top2β-/- mice at e11.5. Scale bar = 50 μm. E–H, Hox protein expression levels in control and Top2β-/- mice at e11.5. Levels of Hoxc6 (p = 0.007), Hoxc8 (p = 2.4 × 10−5), and Hoxc9 (p = 0.04) are decreased while Hoxa5 levels (p = 0.84) are unchanged. Scale bar = 50 μm.
