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Mean (±SD) change from baseline in self-assessed severity of dyspareunia (A), vaginal irritation/itching (B), and vaginal dryness (C; mITT Population). Dyspareunia, vaginal/vulvar irritation/itching, and vaginal dryness, severity scores: 0 = none, 1 = mild, 2 = moderate, 3 = severe. Data for final assessment for vaginal dryness was a coprimary endpoint and is reported in Table 2 above. ∗∗∗P < 0.001; ∗∗P < 0.01; panels A and C; vs estradiol, panel B. mITT, modified intent-to-treat.
