Table 2.
Common adjuvant therapy regimens doses and schedules.
| Medication/regimen | Dose | Schedule | Ref. |
|---|---|---|---|
| Endocrine therapies | |||
| Tamoxifen | 20 mg | Daily | |
| Aromatase inhibitors: – Anastrozole – Letrozole – Exemestane |
1 mg 2.5 mg 25 mg |
Daily Daily Daily |
|
| Chemotherapy | |||
| Cyclophosphamide Methotrexate 5-fluorouracil (CMF) |
600 mg/m2 40 mg/m2 600 mg/m2 |
Every 21 days for 8 cycles | [52] |
| Docetaxel Cyclophosphamide (TC) |
75 mg/m2 600 mg/m2 |
Every 3 weeks for 4 cycles | [53] |
| Adriamycin Cyclophosphamide (AC) |
60 mg/m2 600 mg/m2 |
Every 3 weeks for 4 cycles | [54] |
| Dose dense Adriamycin Cyclophosphamide Paclitaxel (AC-T) |
60 mg/m2 600 mg/m2 175 mg/m2 |
AC every 2 weeks for 4 cycles and paclitaxel every 2 weeks for 4 cycles with granulocyte growth factor support | [55] |
| Anti HER-2 directed regimens | |||
| Docetaxel Carboplatin Trastuzumab (TCH) |
75 mg/m2 AUC 6 4 mg/kg loading dose then 2 mg/kg/week |
Every 3 weeks for 6 cycles followed by single agent trastuzumab to complete one year | [56] |
| Paclitaxel Trastuzumab (TH) |
80 mg/m2 4 mg/kg loading dose then 2 mg/kg/week |
Every week for 12 cycles followed by single agent trastuzumab to complete 1 year | [57] |
AUC: Area under the plasma drug concentration vs time curve.