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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Prog Retin Eye Res. 2017 Oct 16;62:1–23. doi: 10.1016/j.preteyeres.2017.10.002

Figure 6. Valproic acid worsens photoreceptor function and survival in P23H-1 rats.

Figure 6

P23H-1 rats were received VPA (7.1 gm/Liter) in drinking water (n=9) or water (n=8) from P21-P35. (A) Scotopic ERG’s were performed as previously described (Athanasiou et al., 2017a) at -5 to 1-log intensities (data not shown). Average at 0 log cds/m2 for a-wave and b-wave of P23H-1 rats showing significant reduction of a-wave in VPA-treated animals (**p<0.01). The b-wave is not significantly affected (n.s) by VPA treatment. Values are mean ± SEM. Unpaired two-sided Student's t test. (B) OCT analysis was performed as previously described (Athanasiou et al., 2017a) across the nasal-temporal meridian. The mean ONL thickness across the whole retina is significantly reduced in VPA-treated animals (**p<0.001). Values are mean ± SEM. Unpaired two-sided Student's t test.