Table 4.
Commonly used mammalian models of rhodopsin RP (KO = knock-out; KI = knock-in; Tg = transgenic).
| Mutation | Species | Methodology | Reference(s) |
|---|---|---|---|
| Rho KO | Mouse | Homologous recombination | Humphries et al., (1997) Lem et al., (1999) |
| T4R | Dog | Spontaneous | Kijas et al (2002) |
| T17M (Tg) | Mouse | Human Transgene | Li et al (1998) |
| V20G-P23H-P27L (VPP) (Tg) |
Mouse | Mouse Transgene | Naash et al., (1993) |
| P23H (Tg) | Mouse | Human Transgene | (Olsson et al., 1992) |
| P23H (KI) | Mouse | Homologous recombination | Sakami et al., (2011) |
| P23H-GFP (KI) | Mouse | RHO-GFP Homologous Recombination |
Price et al., (2011) |
| P23H (Tg) | Rat P23H Line 1 (P23H-1) P23H Line 2 (P23H-2) P23H Line 3 (P23H-3) |
Mouse Transgene (1 high copy=fast) (3=slow) |
Pennesi et al., (2008) |
| P23H (Tg) | Pig | Human Transgene | Ross et al., (2011) |
| G90D (Tg) | Mouse | Mouse Transgene | Sieving et al., (2001) |
| E150K (KI) | Mouse | Homologous recombination | Zhang et al (2013) |
| S334ter (Tg) | Rat S334ter Line 3 (S334ter-3) S334ter Line 4 (S334ter-4) S334ter Line 5 (S334ter-5) S334ter Line 7 (S334ter-7) S334ter Line 9 (S334ter-9) |
Mouse Transgene | Pennesi et al., (2008) |
| Q344ter (Tg) | Mouse | Mouse Transgene | Sung et al., (1994) |
| P347L (Tg) | Rabbit | Rabbit Transgene | Kondo et al., (2009) |
| P347L (Tg) | Pig | Pig Transgene | Petters et al., (1997) |
| P347S (Tg) | Mouse | Human Transgene | Li et al., (1996) |
| P347S (Tg) | Pig | Pig Transgene | Kraft et al., (2005) |