Table 2.

Differential expression proteins in cohort 1

Accession no.	Gene symbol	P value	Number L-BMD	Number H-BMD	Regulation direction
IPI00979518.1	CFL1	1.55 × 10−3	6	7	Up
IPI00220278.5	MYL9	7.29 × 10−3	5	8	Up
IPI00847989.3	PKM2	8.21 × 10−3	8	10	Up
IPI00337335.8	MYH14	1.12 × 10−2	13	13	Up
IPI00795257.3	GAPDH	1.15 × 10−2	14	12	Up
IPI00908876.1	ALB	1.20 × 10−2	5	7	Up
IPI00005161.3	ARPC2	1.29 × 10−2	17	17	Up
IPI00708398.2	ALB	1.40 × 10−2	28	30	Down
IPI00374975.2	PGAM4	1.66 × 10−2	19	21	Up
IPI00013508.5	ACTN1	1.91 × 10−2	24	23	Up
IPI00003362.3	HSPA5	2.89 × 10−2	25	26	Up
IPI00784258.3	LTBP1	3.13 × 10−2	5	5	Up
IPI01014435.1	RAP1B	3.41 × 10−2	8	10	Up
IPI01013638.1	LDHC	4.19 × 10−2	9	11	Up
IPI00555614.1	HSP90AB3P	4.19 × 10−2	16	17	Up
IPI00216134.3	TPM1	4.25 × 10−2	11	7	Up
IPI00218319.3	TPM3	5.05 × 10−2	6	11	Up
IPI00877792.1	FGG	5.14 × 10−2	8	8	Down
IPI00796333.1	ALDOA	5.38 × 10−2	7	11	Up
IPI00297579.4	CBX3	5.78 × 10−2	9	7	Up
IPI00236556.1	MPO	5.81 × 10−2	8	11	Up
IPI00979275.1	LOC652797	6.11 × 10−2	7	15	Up
IPI00894365.2	ACTB	6.25 × 10−2	5	5	Down
IPI01012981.1	P4HB	6.25 × 10−2	8	5	Up
IPI00939159.6	CAP1	6.78 × 10−2	23	25	Up
IPI00013122.1	CDC37	6.82 × 10−2	14	13	Up
IPI00909140.8	TUBB	7.26 × 10−2	11	14	Up
IPI00465248.5	ENO1	7.31 × 10−2	29	29	Up
IPI00549725.6	PGAM1	7.32 × 10−2	24	24	Up
IPI00219713.1	FGG	7.43 × 10−2	20	13	Up
IPI00026314.1	GSN	7.53 × 10−2	8	5	Up
IPI00853115.1	NEFM	8.06 × 10−2	20	24	Up
IPI00031523.4	HSP90AA2	8.39 × 10−2	12	12	Up
IPI00219217.3	LDHB	8.55 × 10−2	25	27	Up
IPI01012504.1	PGD	8.56 × 10−2	13	14	Up
IPI00296099.6	THBS1	9.37 × 10−2	29	30	Up
IPI00148061.3	LDHAL6A	9.64 × 10−2	15	18	Up
IPI00020599.1	CALR	9.78 × 10−2	22	25	Up

The DEPs identified in discovery study are listed in this table, including 16 proteins that showed significant (P < 0.05) differential expression between low vs. high BMD groups and an additional 22 proteins showed suggestive (P < 0.1) evidence for differential expressions. Regulated direction shows the regulation direction of proteins in subjects with low hip BMDs