Table 4.
Multiple-omics level analysis
| Gene symbol | Proteomics
|
Transcriptomics
|
GWAS
|
Meta-analysis
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cohort 1
|
Cohort 2
|
Cohort 3
|
Cohort 4
|
Cohort 5
|
Cohort 6
|
P value | Padj value | |||||||
| P value | Probe ID | P value | Probe ID | P value | Probe ID | P value | Probe ID | P value | Probe ID | P value | Probe ID | |||
| MYH14 | 1.12 × 10−2 | IPI00337335.8 | ND | ND | ND | ND | ND | ND | 4.66 × 10−1 | 219946_x_at | 2.15 × 10−3 | rs139086374 | 8.70 × 10−4 | 7.00 × 10−3 |
| RAP1B | 3.41 × 10−2 | IPI01014435.1 | 6.07 × 10−1 | 3,421,118 | ND | ND | ND | ND | ND | ND | 1.40 × 10−3 | rs73332537 | 1.91 × 10−3 | 1.01 × 10−2 |
| ALDOA | 5.38 × 10−2 | IPI00796333.1 | 3.80 × 10−1 | 3,655,920 | ND | ND | ND | ND | 8.66 × 10−1 | 200966_x_at | 4.13 × 10−3 | rs184768500 | 4.59 × 10−3 | 4.06 × 10−2 |
DEPs in this table have supported evidence from all three biological levels. In cohorts from mRNA expression data, genes have consistent expression trends with those in cohort 1. ND means no detected signal. Presented are the smallest P values and corresponding probes in studies of mRNA expression and SNPs association. Meta P value indicates a general score for each gene of DEPs which combine the meta-scores from protein expression, mRNA expression, and SNP association data. Padj values means the P values which were adjusted using FDR in order to correct for multiple hypothesis testing. These significant P values and Padj values are shown as italicized (P < 0.05)