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. Author manuscript; available in PMC: 2019 Jan 22.
Published in final edited form as: Angew Chem Int Ed Engl. 2018 Jan 2;57(4):967–971. doi: 10.1002/anie.201706535

Figure 4.

Figure 4

Cell-surface in situ glycan editing modulate the hERG channel functions. a) The pulse protocol for whole-cell voltage clamp experiment. Cells were held at −80mV and depolarized to pre-pulse potential ranging from −60 to +40 mV with 10-mV increments for 4 s, followed by a −40 mV repolarizing step. Arrows indicate points at which currents were measured (solid: for I–V curves, dash: for SSA curves). b) SSA curves for hERG channels in untreated and in situ Sia edited cells (n = 6–8). Lines are fits of the data to single Boltzmann distributions. c) The normalized maximal tail current for hERG channels in untreated and in situ Fuc edited cells (n =6, **p <0.01).