Table 1.
pCaMKII-T286 IR in specific brain regions following cue-induced reinstatement of alcohol-seeking behavior vs. extinction control.
| Brain region | Extinction | Reinstatement | |
|---|---|---|---|
| Nucleus accumbens | Core | 167.0 ± 42.9 | 207.2 ± 34.8 |
| Shell | 153.8 ± 28.5 | 284.5 ± 23.9a | |
| Dorsal striatum | Medial | 128.6 ± 48.6 | 116.6 ± 25.2 |
| Lateral | 87.9 ± 45.2 | 51.9 ± 12.7 | |
| Septum | Medial | 247.7 ± 24.1 | 233.8 ± 31.7 |
| Lateral | 221.9 ± 37.5 | 324.7 ± 25.8a | |
| Piriform cortex | 116.3 ± 19.5 | 165.1 ± 14.9a | |
| Cingulate cortex | CG1 | 441.6 ± 111.2 | 396.9 ± 131.4 |
| CG2 | 287.8 ± 52.2 | 323.3 ± 16.1 | |
| Septohippocampal nucleus | 171.6 ± 27.7 | 191.2 ± 33.3 | |
| Amygdala | Lateral | 149.6 ± 25.6 | 299.3 ± 58.9a |
| Basolateral | 112.3 ± 26.6 | 262.6 ± 61.7a | |
| Central | 231.1 ± 22.1 | 263.6 ± 33.8 | |
| Habenula | Lateral | 182.2 ± 34.9 | 211.8 ± 38.2 |
| Thalamus | Paraventricular | 219.1 ± 53.5 | 272.8 ± 39.0 |
| Intermediodorsal | 234.0 ± 27.0 | 271.9 ± 47.3 | |
| Mediodorsal | 166.9 ± 43.5 | 229.6 ± 41.8a | |
| Reuniens | 195.4 ± 58.5 | 168.6 ± 42.1 | |
| Hypothalamus | Ventromedial | 195.8 ± 37.9 | 211.6 ± 20.0 |
| Dorsomedial | 193.4 ± 30.4 | 195.5 ± 41.9 |
Data represent MEAN ± SEM cells/mm2.
a
Indicates statistically different from Extinction, t-test.