Emerging network underlying guinea pig HF. Pathway analysis and upstream activator analysis predicted cAMP and retinoic acid deficiencies in guinea pig HF. Here we indicate the inferred impact on cAMP- and RA-responsive transcriptional programs, including Creb, CREBBP, RXRA, PGC1a, BDNF, and MEF2C. Inhibition of the programs (top; blue) is consistent with the proteomic profile observed in HF (downregulation in green, upregulation in red). CP denotes canonical pathway involvement. Tx denotes inferred toxic or pathological sequelae.