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. Author manuscript; available in PMC: 2018 Jan 23.
Published in final edited form as: J Proteome Res. 2016 Aug 3;15(9):3009–3028. doi: 10.1021/acs.jproteome.6b00149

Figure 7.

Figure 7

Emerging network underlying guinea pig HF. Pathway analysis and upstream activator analysis predicted cAMP and retinoic acid deficiencies in guinea pig HF. Here we indicate the inferred impact on cAMP- and RA-responsive transcriptional programs, including Creb, CREBBP, RXRA, PGC1a, BDNF, and MEF2C. Inhibition of the programs (top; blue) is consistent with the proteomic profile observed in HF (downregulation in green, upregulation in red). CP denotes canonical pathway involvement. Tx denotes inferred toxic or pathological sequelae.