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. Author manuscript; available in PMC: 2018 Jan 23.
Published in final edited form as: J Proteome Res. 2016 Aug 3;15(9):3009–3028. doi: 10.1021/acs.jproteome.6b00149

Table 2.

Excitation–Contraction Coupling Channels and Transporters Regulated in the Transcriptome

transcript accession no. gene name gene HYP/shama HF/shama HF/HYPa
20071073 hyperpolarization activated cyclic nucleotide-gated potassium channel 1 HCN1 3.24* 7.19* 2.22
20141937 ATPase, Na+/K+ transporting, β4 polypeptide ATP1B4 2.22* 3.85* 1.73
20126631 ATPase, Na+/K+ transporting, α2 polypeptide ATP1A2 1.52* 2.2* 1.45
20034606 transient receptor potential cation channel, subfamily C, member 6 TRPC6 1.46* 2.10* 1.44
20033943 sodium channel, voltage-gated, type III, β subunit SCN3B 1.62* 2.07 1.27
20083068 purinergic receptor P2X, ligand-gated ion channel 5 P2RX5 1.19 1.76* 1.47
20126168 sodium channel, voltage-gated, type I, β subunit SCN1B 1.24* 1.75* 1.41*
20099829 transient receptor potential cation channel, subfamily V, member 4 TRPV4 1.54* 1.71* 1.11
20123770 calcium channel, voltage-dependent, T type, α1G subunit CACNA1G 1.66* 1.4 0.84
20041090 potassium voltage-gated channel, shaker-related subfamily, member 3 KCNA3 1.17 1.37* 1.17
20133876 phosphoinositide-interacting regulator of transient receptor potential channels PIRT 1.33* 1.37* 1.03
19983232 potassium voltage-gated channel, Isk-related family, member 3 KCNE3 1.07 1.31* 1.23*
20041789 chloride channel accessory 4 CLCA4 0.87 1.31* 1.51*
20020072 potassium channel, subfamily K, member 1 KCNK1 1.29 1.29* 1
20098740 potassium channel tetramerization domain containing 13 KCTD13 0.95 1.28* 1.34*
20156521 ATPase, Na+/K+ transporting, β3 polypeptide ATP1B3 1.07 1.27* 1.19
20068238 potassium channel tetramerization domain containing 17 KCTD17 1.21* 1.23* 1.01
20062018 potassium voltage-gated channel, shaker-related subfamily, β member 2 KCNAB2 1.33* 1.22 0.92
20012481 chloride intracellular channel 2 CLIC2 1.22 1.22* 1
20056824 potassium channel tetramerization domain containing 8 KCTD8 1.34* 1.20* 0.89
20012102 potassium voltage-gated channel, Isk-related subfamily, member 1 KCNE1 1.01 1.19* 1.17
20060071 gap junction protein, β5, 31.1 kDa GJB5 1.3* 1.18 0.9
19998760 calcium channel, voltage-dependent, β2 subunit CACNB2 0.96 1.16* 1.20*
19984710 potassium voltage-gated channel, subfamily G, member 2 KCNG2 1.27* 1.16 0.91
20060736 chloride intracellular channel 4 CLIC4 1.04 1.15* 1.11
20038373 potassium voltage-gated channel, Shaw-related subfamily, member 4 KCNC4 0.82 1.14 1.39*
20092226 potassium channel modulatory factor 1 KCMF1 1.06 1.13* 1.07
20152309 transmembrane channel-like 8 TMC8 1.38* 1.13 0.82*
19975667 potassium channel tetramerization domain containing 9 KCTD9 0.95 1.12* 1.18*
20037512 sodium channel modifier 1 SCNM1 0.95 1.12 1.18*
20117862 potassium channel tetramerization domain containing 12 KCTD12 1.23* 1.1 0.9
19966992 transient receptor potential cation channel, subfamily A, member 1 TRPA1 0.93 1.1 1.19*
20090690 chloride channel 3 CLCN3 1.17* 1.09 0.93
19997489 ATPase, Ca2+ transporting, plasma membrane 4 ATP2B4 1.26* 1.08 0.86
20124300 calcium channel, voltage-dependent, β1 subunit CACNB1 0.89 1.06 1.19*
20030731 calcium channel, voltage-dependent, N type, α1B subunit CACNA1B 1.32* 1.06 0.8
20107097 two pore segment channel 2 TPCN2 1.14* 0.97 0.85
20112569 potassium channel, subfamily K, member 15 KCNK15 1.13 0.93 0.83*
20048710 potassium channel tetramerization domain containing 19 KCTD19 1.12 0.93 0.83*
20038626 ATPase, Na+/K+ transporting, α1 polypeptide ATP1A1 0.91* 0.93 1.02
19969465 potassium voltage-gated channel, Shab-related subfamily, member 2 KCNB2 0.72* 0.92 1.28
20003587 potassium voltage-gated channel, subfamily H (eag-related), member 1 KCNH1 1.22* 0.9 0.74*
19976195 gap junction protein, α1 GJA1 1.12* 0.9 0.8*
20140559 gap junction protein, γ1, 45 kDa GJC1 1.05 0.87* 0.83*
20061238 chloride channel, voltage-sensitive Kb CLCNKB 0.87 0.86* 0.99
19992472 ATPase, Ca2+ transporting, cardiac muscle, slow twitch 2 ATP2A2 0.91 0.86* 0.94
20060065 gap junction protein, α4, 37 kDa GJA4 0.91* 0.86* 0.94
20097353 potassium channel tetramerization domain containing 5 KCTD5 0.74* 0.86 1.15
20013102 ATPase, Ca2+ transporting, plasma membrane 3 ATP2B3 0.71* 0.86 1.21
19970564 potassium voltage-gated channel, subfamily H (eag-related), member 8 KCNH8 0.98 0.85* 0.87*
20115178 potassium large conductance calcium-activated channel, subfamily M, β KCNMB3 0.9 0.84* 0.94
member 3
19983489 short transient receptor potential channel 2-like LOC100715102 0.93 0.82* 0.88
20030467 potassium voltage-gated channel, subfamily G, member 3 KCNG3 0.99 0.82* 0.83
20098428 sodium channel, nonvoltage-gated 1γ SCNN1G 0.86 0.82* 0.94
20082999 purinergic receptor P2X, ligand-gated ion channel 1 P2RX1 0.82* 0.81* 0.99
20003217 potassium channel tetramerization domain containing 3 KCTD3 0.94 0.81* 0.86
20069544 potassium inwardly rectifying channel, subfamily J, member 8 KCNJ8 0.78* 0.81 1.05
19999618 potassium voltage-gated channel, subfamily F, member 1 KCNF1 0.92 0.80* 0.87
20124749 potassium voltage-gated channel, subfamily H (eag-related), member 4 KCNH4 0.89 0.80* 0.9
19994143 potassium voltage-gated channel, KQT-like subfamily, member 2 KCNQ2 0.87 0.79* 0.9
20109067 potassium voltage-gated channel, subfamily Q, member 1 KCNQ1 0.93 0.79* 0.85
20081931 acid-sensing (proton-gated) ion channel 3 ASIC3 1 0.78* 0.78*
19975338 potassium channel, subfamily K, member 18 KCNK18 0.92 0.78* 0.85
20083093 transient receptor potential cation channel, subfamily V, member 1 TRPV1 0.75 0.76* 1
20137866 potassium voltage-gated channel, subfamily H (eag-related), member 6 KCNH6 0.88 0.75* 0.86
20074714 potassium inwardly rectifying channel, subfamily J, member 2 KCNJ2 0.93 0.74* 0.8
20041088 potassium voltage-gated channel, shaker-related subfamily, member 2 KCNA2 1.01 0.74* 0.73
20004743 transient receptor potential cation channel, subfamily M, member 8 TRPM8 0.89 0.74* 0.83
20138900 calcium channel, voltage-dependent, γ subunit 5 CACNG5 0.82 0.73* 0.89
20020195 ryanodine receptor 2 (cardiac) RYR2 0.84* 0.68* 0.81
19969815 calcium channel, voltage-dependent, α2/δ subunit 3 CACNA2D3 0.65* 0.66* 1.01
20138895 calcium channel, voltage-dependent, γ subunit 4 CACNG4 0.9 0.63* 0.71*
20147496 calcium channel, voltage-dependent, γ subunit 7 CACNG7 0.87 0.61* 0.7
20164942 ATPase, Ca2+ transporting, plasma membrane 2 ATP2B2 0.86 0.61* 0.7*
20034895 potassium inwardly rectifying channel, subfamily J, member 5 KCNJ5 0.76 0.56* 0.73
a

Asterisks (*) denote p < 0.05.