Table 3.
Current alcohol use and risk of invasive ductal, invasive lobular, and invasive ducal-lobular breast cancer by ER status
| Controls (n = 891) | ER+ ductal cases (n = 735) | ER- ductal cases (n = 156) | ER+ lobular cases (n = 538) | ER+ ductal-lobular cases (n = 459) | |||||
|---|---|---|---|---|---|---|---|---|---|
| No.(%) | No.(%) | OR (95% CI)a | No.(%) | OR (95% CI)a | No.(%) | OR (95% CI)a | No.(%) | OR (95% CI)a | |
| Alcohol use | |||||||||
| Never | 323 (36.3) | 249 (33.9) | 1 [Ref] | 60 (38.5) | 1 [Ref] | 178 (33.1) | 1 [Ref] | 167 (36.4) | 1 [Ref] |
| Former | 126 (14.1) | 88 (12.0) | 0.91 (0.66, 1.26) | 33 (21.2) | 1.39 (0.86, 2.23) | 70 (13.0) | 1.02 (0.72, 1.44) | 52 (11.3) | 0.77 (0.53, 1.12) |
| Current | 442 (49.6) | 398 (54.2) | 1.16 (0.94, 1.44) | 63 (40.4) | 0.72 (0.49, 1.05) | 290 (53.9) | 1.22 (0.96, 1.55) | 240 (52.3) | 1.01 (0.79, 1.29) |
| Average no.of drinks/week at reference | |||||||||
| <4 Drinks | 242 (27.2) | 200 (27.2) | 1.07 (0.83, 1.38) | 37 (23.7) | 0.76 (0.48, 1.18) | 134 (24.9) | 1.02 (0.77, 1.35) | 122 (26.6) | 0.94 (0.70, 1.25) |
| 4–<7 drinks | 64 (7.2) | 67 (9.1) | 1.34 (0.92, 1.97) | 8 (5.1) | 0.62 (0.28, 1.36) | 49 (9.1) | 1.45 (0.96, 2.21) | 32 (7.0) | 0.92 (0.57, 1.46) |
| ≥7 drinks | 136 (15.3) | 131 (17.8) | 1.25 (0.93, 1.67) | 18 (11.5) | 0.69 (0.39, 1.21) | 107 (19.9) | 1.47 (1.07, 2.01) | 86 (18.7) | 1.17 (0.84, 1.63) |
| P trend | 0.02 | 0.01 | 0.002 | 0.36 | |||||
aOR (95% CI) adjusted for age, reference year, and county of reference