Table 3. Relationship of KIR haplotypes and genotypes with perinatal transmission of HIV-1.
HIV Non- Transmitter % N = 260 |
HIV Transmitter % N = 53 |
Unadjusted Odds ratio (95% CIa) |
P value | Adjusted Odds ratiob (95% CIa) |
P value | |
---|---|---|---|---|---|---|
Infant | ||||||
KIR Haplotype | ||||||
Haplotype A | 37.8 | 35.9 | 0.93 (0.50–1.70) | 0.82 | 1.29 (0.63–2.62) | 0.48 |
Haplotype Bc | 62.3 | 64.2 | 1 | — | 1 | — |
KIR Genotype | ||||||
AA | 37.3 | 34.0 | 0.86 (0.46–1.58) | 0.64 | 1.15 (0.56–2.33) | 0.70 |
ABc | 61.9 | 66.0 | 1 | — | — | |
BB | 0.8 | 0.0 | 0.91 (0.01–11.50) | 0.95 | 0.62 (0.004–11.75) | 0.77 |
Mother | ||||||
KIR Haplotype | ||||||
Haplotype A | 33.5 | 47.2 | 1.77(0.98–3.21) | 0.060 | 1.74 (0.86–3.70) | 0.14 |
Haplotype Bc | 66.5 | 52.8 | 1 | — | 1 | — |
KIR Genotype | ||||||
AA | 32.7 | 47.2 | 1.82 (1.00–3.29) | 0.050 | 1.79 (0.86–3.70) | 0.12 |
ABc | 66.5 | 52.8 | 1 | — | 1 | — |
BB | 0.8 | 0.0 | 1.22(0.01–15.48) | 0.90 | 2.35 (0.02–33.11) | 0.62 |
Note: Logistic regression with Firth likelihood penalty was used for all models.
aCI = Confidence interval.
bAdjusted odds ratios derived from multivariable logistic regression controlling for CD4 cell count, viral load, and gravidity.
cReference group was selected based on the group with highest frequency. False Discovery Rate (FDR) correction was used to determine significance.