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. 2018 Jan 23;13(1):e0191733. doi: 10.1371/journal.pone.0191733

Table 3. Relationship of KIR haplotypes and genotypes with perinatal transmission of HIV-1.

HIV Non-
Transmitter %
N = 260
HIV
Transmitter %
N = 53
Unadjusted Odds ratio
(95% CIa)
P value Adjusted Odds ratiob
(95% CIa)
P value
Infant
KIR Haplotype
Haplotype A 37.8 35.9 0.93 (0.50–1.70) 0.82 1.29 (0.63–2.62) 0.48
Haplotype Bc 62.3 64.2 1 1
KIR Genotype
AA 37.3 34.0 0.86 (0.46–1.58) 0.64 1.15 (0.56–2.33) 0.70
ABc 61.9 66.0 1
BB 0.8 0.0 0.91 (0.01–11.50) 0.95 0.62 (0.004–11.75) 0.77
Mother
KIR Haplotype
Haplotype A 33.5 47.2 1.77(0.98–3.21) 0.060 1.74 (0.86–3.70) 0.14
Haplotype Bc 66.5 52.8 1 1
KIR Genotype
AA 32.7 47.2 1.82 (1.00–3.29) 0.050 1.79 (0.86–3.70) 0.12
ABc 66.5 52.8 1 1
BB 0.8 0.0 1.22(0.01–15.48) 0.90 2.35 (0.02–33.11) 0.62

Note: Logistic regression with Firth likelihood penalty was used for all models.

aCI = Confidence interval.

bAdjusted odds ratios derived from multivariable logistic regression controlling for CD4 cell count, viral load, and gravidity.

cReference group was selected based on the group with highest frequency. False Discovery Rate (FDR) correction was used to determine significance.