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. 2018 Jan 19;97(3):e9632. doi: 10.1097/MD.0000000000009632

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Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

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Demographic history of Bulgarian HAV genotype I (subtype Ib: panel a; subtype Ia: panel b). The demographic history was inferred by a nonparametric Bayesian skyline plot (BSP). The y-axis reports virus effective population size (Ne), a measure of genetic diversity representing the number of genomes effectively contributing to new infections, while the x-axis is time in calendar years. Black lines are median estimates; purple lines are 95% highest posterior density intervals. BSP = Bayesian skyline plot, HAV = hepatitis A virus.