Table 3.
Association between selected characteristics and sero‐response proportion (>fourfold‐rise) after vaccination
| Category | n | n (%, 95%CI) | Univariate analysis | Mutivariate model* | ||
|---|---|---|---|---|---|---|
| OR (95%CI) | P value | OR (95%CI) | P value | |||
| Age (years) | ||||||
| <62 | 24 | 20 (83, 68–98) | 1·00 | 1·00 | ||
| 62–69 | 28 | 23 (82, 68–96) | 0·92 (0·22–3·90) | 0·91 | 1·12 (0·18–6·76) | 0·91 |
| 70+ | 27 | 14 (52, 33–71) | 0·22 (0·06–0·80) | 0·02 | 0·46 (0·09–2·43) | 0·36 |
| Trend P = 0·01 | Trend P = 0·25 | |||||
| Body mass index (kg/m2) | ||||||
| <20·2 | 26 | 16 (62, 43–81) | 0·22 (0·05–0·92) | 0·04 | 0·20 (0·03–1·18) | 0·07 |
| 20·2–22·5 | 28 | 19 (68, 51–85) | 0·29 (0·07–1·22) | 0·09 | 0·36 (0·06–2·10) | 0·26 |
| 22·6+ | 25 | 22 (88, 75–100) | 1·00 | 1·00 | ||
| Trend P = 0·04 | Trend P = 0·07 | |||||
| 2009/10 seasonal influenza vaccination | ||||||
| Unvaccinated | 48 | 41 (85, 75–95) | 1·00 | 1·00 | ||
| Vaccinated | 31 | 16 (52, 34–70) | 0·18 (0·06–0·53) | <0·01 | 0·21 (0·04–1·07) | 0·06 |
| Time elapsed between seasonal vaccination and A(H1N1)pdm09 vaccination | ||||||
| Unvaccinated | 48 | 41 (85, 75–95) | 1·00 | 1·00** | ||
| 21 days or more | 17 | 10 (59, 36–82) | 0·24 (0·07–0·86) | 0·03 | 0·64 (0·08–5·18) | 0·68 |
| Within 20 days | 14 | 6 (43, 17–69) | 0·13 (0·03–0·48) | <0·01 | 0·10 (0·02–0·67) | 0·02 |
| Trend P < 0·01 | Trend P = 0·01 | |||||
| Prevaccination titer | ||||||
| <1:10 | 44 | 36 (82, 71–93) | 1·00 | 1·00 | ||
| 1:10–1:20 | 31 | 20 (65, 48–82) | 0·40 (0·14– 1·17) | 0·10 | 1·04 (0·25–4·35) | 0·95 |
| >1:40 | 4 | 1 (25, 0–67) | 0·07 (0·01–0·81) | 0·03 | 0·21 (0·02–2·80) | 0·24 |
| Trend P = 0·01 | Trend P = 0·41 | |||||
| Current treatment for liver disease | ||||||
| Stronger Neo‐Minophagen C | ||||||
| No | 64 | 50 (78, 68–88) | 1·00 | 1·00 | ||
| Receive | 15 | 7 (47, 22–72) | 0·25 (0·08–0·79) | 0·02 | 0·35 (0·07–1·64) | 0·18 |
| Interferon | ||||||
| No | 48 | 30 (63, 49–77) | 1·00 | 1·00 | ||
| Receive | 31 | 27 (87, 75–99) | 4·05 (1·22–13·5) | 0·02 | 1·29 (0·28–6·06) | 0·75 |
OR, odds ratio; CI, confidence interval.
*Model included all variables in the table.
**The ORs were obtained from the model in which 2009/10 seasonal influenza vaccination was replaced by time elapsed between seasonal vaccination and A(H1N1)pdm09 vaccination.