Figure 1.

Schematic representation of the PDGF signaling pathway. PDGF, platelet-derived growth factor; PDGFR, PDGF receptor; miR, microRNA; PI3K, phosphatidylinositol 3-kinase; PLCγ, phospholipase Cγ; Sos, son of sevenless homolog; JAK1, tyrosine-protein kinase JAK1; PDK1, 3-phosphoinositide-dependent protein kinase 1; Akt, RAC-α serine/threonine protein kinase; PTEN, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; ROCK, Rho-associated protein kinase 1; MLC, membrane protein MLC; NF-κB, nuclear factor-κB; IKKα, inhibitor of NF-κB kinase subunit α; C/EBPβ, CCAAT/enhancer-binding protein β; STAT, signal transducer and activator of transcription; MEK, dual specificity mitogen-activated protein kinase kinase; Erk, extracellular signal-regulated kinase; AP-1, transcription factor AP-1; TIMP, metalloproteinase inhibitor; c-Myc, myc proto-oncogene protein; CT1, cardiotrophin 1.