Table I.

Gene Ontology analysis for differentially expressed genes.

A, Upregulated
Term	Description	Counts (n)	P-valuea
GO-BP terms
GO:0006952	Defense response	44	<0.0005
GO:0006955	Immune response	41	2.22×10−16
GO:0002376	Immune system process	50	3.00×10−15
GO:0001775	Cell activation	31	1.37×10−14
GO:0045321	Leukocyte activation	26	1.76×10−13
GO-CC terms
GO:0005576	Extracellular region	63	2.06×10−12
GO:0005615	Extracellular space	32	4.37×10−12
GO:0031982	Vesicle	53	9.90×10−11
GO:0031988	Membrane-bounded vesicle	52	1.13×10−10
GO:0044421	Extracellular region part	53	3.50×10−10
GO-MF terms
GO:0003823	Antigen binding	8	2.97×10−07
GO:0061134	Peptidase regulator activity	10	6.67×10−07
GO:0005539	Glycosaminoglycan binding	9	2.84×10−07
GO:0004866	Endopeptidase inhibitor activity	8
8092×10−06
GO:0061135	Endopeptidase regulator activity	8	1.11×10−05
B, Downregulated
Term	Description	Counts (n)	P-valuea
GO-BP terms
GO:0072358	Cardiovascular system development	50	3.77×10−15
GO:0072359	Circulatory system development	50	3.77×10−15
GO:0009653	Anatomical structure morphogenesis	91	4.66×10−15
GO:0048731	System development	121	3.40×10−14
GO:0032502	Developmental process	147	5.66×10−14
GO-CC terms
GO:0015629	Actin cytoskeleton	31	1.79×10−12
GO:0030054	Cell junction	47	6.04×10−10
GO:0070161	Anchoring junction	28	1.82×10−09
GO:0005912	Adherens junction	27	3.39×10−09
GO:0044421	Extracellular region part	98	3.00×10−08
GO-MF terms
GO:0008092	Cytoskeletal protein binding	40	9.40×10−11
GO:0005178	Integrin binding	12	1.23×10−07
GO:0032403	Protein complex binding	35	4.24×10−07
GO:0050839	Cell adhesion molecule binding	14	8.04×10−07
GO:0003779	Actin binding	21	1.40×10−06

^aP<0.00001 vs. normal matched tissues. GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function; Term, the identification number of GO; Description, the name of the GO term; Counts, the number of genes enriched in the GO term.