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(A) Resveratrol significantly activated protein expression of SIRT1 in liver cancer cells. (B) EX527 inhibited deacetylase activity of SIRT1 in HepG2 cells. (C) Protein levels of PI3K, p-PI3K, p-AKT and p-FoxO3a after treated with EX527. (D) Protein levels of PI3K, p-PI3K, AKT, p-AKT, FoxO1, Ac-FoxO1, FoxO3a and p-FoxO3a. The bar graphs and representative images are shown. *P<0.05 and **P<0.01 vs. control.
