Table II.
KEGG pathway analysis of upregulated and downregulated differentially expressed genes. Top 5 terms were selected according to P-value when more than five terms enriched terms were identified in each category.
| A, Upregulated | ||||
|---|---|---|---|---|
| Pathway ID | Name | Count | P-value | Genes |
| hsa05131 | Shigellosis | 8 | 5.30×10−4 | ACTB, ARPC2, NFKBIB, ARPC5L, ARPC4, MAPK11, MAPK10, FBXW11 |
| hsa05130 | Pathogenic Escherichia coli infection | 6 | 0.005446999 | ACTB, TUBB, ARPC2, ARPC5L, TUBA4A, ARPC4 |
| hsa04010 | MAPK signaling pathway | 13 | 0.011844961 | NTF3, MRAS, MAPK11, MAPK10, ARRB2, RASGRP1, RASGRP2, PRKACB, FGF1, MYC, GADD45A, RASA1, NFATC1 |
| hsa04014 | Ras signaling pathway | 12 | 0.012462871 | LAT, GRIN2B, MRAS, HTR7, RASGRP1, VEGFA, RASGRP2, GNB4, PRKACB, MAPK10, FGF1, RASA1 |
| hsa05100 | Bacterial invasion of epithelial cells | 6 | 0.030311184 | ACTB, ARPC2, ARPC5L, ARPC4, CD2AP, FN1 |
| B, Downregulated | ||||
| Pathway ID | Name | Count | P-value | Genes |
| hsa05322 | Systemic lupus erythematosus | 10 | 0.006763183 | HIST2H2AA3, HIST1H2AC, HIST1H2BD, HIST1H2BK, HIST2H2BE, HIST2H2AC, HLA-DPA1, C1R, C1S, CD40 |
| hsa04142 | Lysosome | 9 | 0.011440506 | CTSK, LAMP2, TPP1, GUSB, SMPD1, PPT2, NEU1, ATP6V0A4, IDUA |
| hsa00590 | Arachidonic acid metabolism | 6 | 0.019902025 | PLA2G4A, TBXAS1, PTGS1, EPHX2, LTA4H, PLA2G4C |
| hsa05216 | Thyroid cancer | 4 | 0.036016354 | TCF7, RXRA, TFG, TCF7L1 |
| hsa05330 | Allograft rejection | 4 | 0.066232041 | HLA-C, HLA-DPA1, HLA-B, CD40 |
KEGG, Kyoto Encyclopedia of Genes and Genomes.