Table V.
Functional and pathway enrichment analysis of the genes in module. Top 3 terms were selected according to P-value when more than 3 terms enriched terms were identified in each category.
| A, Biological processes | ||||
|---|---|---|---|---|
| Term | Name | Count | P-value | Genes |
| GO:1902476 | Chloride transmembrane transport | 6 | 1.15×10−6 | FXYD1, GLRB, FXYD3, GLRA1, CLIC4, ANO1 |
| GO:0006821 | Chloride transport | 5 | 1.22×10−6 | FXYD1, FXYD3, GLRA1, CLIC4, ANO1 |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | 6 | 8.60×10−6 | EDNRA, PTGER3, CXCR4, SAA1, CCR2, F2R |
| B, Molecular functions | ||||
| Term | Name | Count | P-value | Genes |
| GO:0005254 | Chloride channel activity | 4 | 2.02×10−4 | FXYD1, FXYD3, CLIC4, ANO1 |
| GO:0005525 | GTP binding | 5 | 0.007953298 | GNA14, GUCY1A2, GUCY1A3, TUBA4A, GCH1 |
| GO:0016934 | Extracellular-glycine-gated chloride channel activity | 2 | 0.010379054 | GLRB, GLRA1 |
| C, KEGG pathways | ||||
| Term | Name | Count | P-value | Genes |
| hsa04080 | Neuroactive ligand-receptor interaction | 6 | 0.003899897 | EDNRA, GLRB, PTGER3, GLRA1, GRM7, F2R |
| hsa00230 | Purine metabolism | 5 | 0.00451383 | NME4, NME2, GUCY1A2, GUCY1A3, POLR3A |
| hsa04672 | Intestinal immune network for IgA production | 3 | 0.014264846 | TNFSF13B, CXCR4, CXCL12 |
KEGG, Kyoto Encyclopedia of Genes and Genomes.