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Model for Fibroblasts-airway progenitor cell interaction. The TGF-β signaling inhibits the secretion of HGF in fibroblasts, which binds to its receptor c-Met on airway progenitor cells to promote their growth. Downstream Smad4 may serve as a repressor in the regulating airway progenitor cell function. TGF-β, transforming growth factor-β; HGF, hepatocyte growth factor.
