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. 2017 Oct 4;16(6):8627–8634. doi: 10.3892/mmr.2017.7709

Figure 3.

Figure 3.

miR-494 suppresses cell metastasis in vitro. (A) The number of cells transfected with miR-494 was decreased compared with cells transfected with scramble in the MG-63 and U2OS cells. The restoration of miR-494 significantly repressed cell invasion of MG-63 and U2OS cells. (B) Representative images of MG-63 and U2OS cells under a microscope (magnification, ×200) in the cell invasion assay. (C) Following transfection with miR-494, a decrease in the number of migrated cells was observed, compared with the cells transfected with scramble in the MG-63 and U2OS cells. The restoration of miR-494 significantly repressed the migration of the MG-63 and U2OS cells. (D) Representative images of MG-63 and U2OS cells under a microscope in the cell migration assay. Flow cytometric analysis was used to detect cell cycle distribution in the MG-63 and U2OS cells following transfection with miR-494 or scramble. Overexpression of miR-494 resulted in a promotion of the G1-phase and decrease of the S-phase in the (E) MG-63 and (F) U2OS cells. Flow cytometric analysis of the (G) MG-63 and (H) U2OS cells transfected with miR-494 or scramble. *P<0.05. miR, microRNA.