Table II.

Differentially-expressed genes associated with functions and phenotypes.

Gene symbol	Description	Log2FC	P-value	Gene ontology term
Upregulated
Hbegf	Heparin binding EGF-like growth factor	−2.86	3.79×10−34	Angiogenesis; extracellular space; epidermal growth factor receptor signaling pathway; growth factor activity
Ptgs2	Prostaglandin-endoperoxide synthase 2	−1.88	2.83×10−09	Negative regulation of toll-like receptor signaling pathway; prostaglandin biosynthetic process;
Cxcl2	C-X-C motif chemokine ligand 2	−3.97	3.80×10−07	Cytokine activity; extracellular region; inflammatory response; G-protein coupled receptor signaling pathway; neutrophil chemotaxis
Tgf-β1	Transforming growth factor-β1	−1.48	1.55×10−06	Transcription coactivator activity; focal adhesion; positive regulation of epithelial to mesenchymal transition; Wnt signaling pathway
IL-1β	Interleukin-1β	−2.58	2.28×10−04	Activation of MAPK activity; positive regulation of protein phosphorylation cytokine activity
Downregulated
Ins2	Insulin II	5.01	7.42×10−11	Negative regulation of transcription from RNA polymerase II promoter; MAPK cascade; negative regulation of acute inflammatory response; extracellular region
Tsc1	Tuberous sclerosis 1	1.31	4.44×10−09	Regulation of cell-matrix adhesion; adaptive immune response; protein binding; cytoplasm
Sgk2	Serine/threonine kinase 2	1.22	1.06×10−08	Nucleotide binding; regulation of cell growth; protein serine/threonine kinase activity; cytoplasm
Erbb3	Erb-B2 receptor tyrosine kinase 3	1.07	3.75×10−07	Nucleotide binding; protein kinase activity; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; protein binding
Adgrb1	Adhesion G protein-coupled receptor B1	1.17	1.24×10−06	Transmembrane signaling receptor activity; G-protein coupled receptor activity; protein binding; plasma membrane

FC, fold change; MAPK, mitogen-activated protein kinase.