Table II.

Differently expressed miRNAs in human MIBC tissues.

MIBC tissues vs. normal bladder tissues. (P<0.05, Fold-change >1.5)
miRNA	Change	P-value	Featurea	Rankb
hsa-miR-4786-5p	−10.205618	0.00124	Down	1
hsa-miR-490-3p	−35.773813	0.001358	Down	2
hsa-miR-3617-5p	−42.647285	0.001476	Down	3
hsa-miR-490-5p	−75.331847	0.001594	Down	4
hsa-miR-139-3p	−32.552806	0.001712	Down	5
hsa-miR-133b	−121.234878	0.00183	Down	6
hsa-miR-145-3p	−9.840205	0.001948	Down	7
hsa-miR-29b-1-5p	−10.581222	0.002066	Down	8
hsa-miR-155-5p	8.720112	0.002184	UP	9
hsa-miR-1	−40.712728	0.002302	Down	10
hsa-miR-548q	−5.779384	0.00242	Down	11
hsa-miR-133a-5p	−17.075477	0.002774	Down	12
hsa-miR-146b-5p	4.140864	0.002893	UP	13
hsa-miR-28-3p	−3.834537	0.003129	Down	14
hsa-miR-30c-2-3p	−11.293849	0.003247	Down	15
hsa-miR-143-5p	−15.820855	0.003365	Down	16
hsa-miR-6511b-3p	−6.432579	0.003601	Down	17
hsa-miR-320e	−3.630028	0.003719	Down	18
hsa-miR-99a-3p	−2.325859	0.003837	Down	19
hsa-miR-30a-3p	−18.900354	0.003955	Down	20
hsa-miR-133a-3p	−63.82892	0.004073	Down	21
hsa-miR-4510	−2.805811	0.004545	Down	22
hsa-miR-139-5p	−12.808018	0.004782	Down	23
hsa-miR-4324	−19.035251	0.005136	Down	24
hsa-miR-145-5p	−3.499059	0.005372	Down	25
hsa-miR-125b-1-3p	−13.117689	0.005608	Down	26
hsa-miR-143-3p	−3.894089	0.005962	Down	27
hsa-miR-193a-5p	−4.050292	0.006198	Down	28
hsa-miR-5684	−4.681531	0.007261	Down	29
hsa-miR-328-3p	−8.31845	0.007379	Down	30
hsa-miR-4429	−2.76178	0.007497	Down	31
hsa-miR-1287-5p	−7.357196	0.007615	Down	32
hsa-miR-3605-5p	−2.739437	0.007969	Down	33
hsa-miR-338-5p	−4.852428	0.008323	Down	34
hsa-miR-193a-3p	−9.317892	0.00856	Down	35
hsa-miR-4257	−3.696435	0.008796	Down	36
hsa-miR-6507-5p	−6.813232	0.010331	Down	37
hsa-miR-6722-3p	−2.904131	0.011275	Down	38
hsa-miR-497-5p	−3.273151	0.011865	Down	39
hsa-miR-125b-2-3p	−7.613095	0.012574	Down	40
hsa-miR-29b-2-5p	−2.995467	0.013046	Down	41
hsa-miR-6511a-3p	−8.396761	0.013282	Down	42
hsa-miR-628-3p	−4.613832	0.013636	Down	43
hsa-miR-378b	−6.024561	0.014581	Down	44
hsa-miR-664a-5p	−6.119249	0.014699	Down	45
hsa-miR-204-5p	−6.006885	0.015525	Down	46
hsa-miR-7641	−4.116459	0.015762	Down	47
hsa-miR-320d	−2.149376	0.016706	Down	48
hsa-miR-3656	−2.093619	0.017414	Down	49
hsa-miR-1273g-3p	−2.156204	0.017769	Down	50
hsa-miR-378g	−7.277976	0.018359	Down	51
hsa-miR-1225-5p	−2.552195	0.019067	Down	52
hsa-miR-3156-5p	−6.520017	0.019421	Down	53
hsa-miR-383-5p	−3.70084	0.019658	Down	54
hsa-miR-3064-3p	−2.07381	0.020012	Down	55
hsa-miR-378d	−5.5391	0.02013	Down	56
hsa-miR-23b-5p	−9.113128	0.020366	Down	57
hsa-miR-3195	−10.384316	0.020484	Down	58
hsa-miR-100-5p	−3.57042	0.020956	Down	59
hsa-miR-378e	−14.003579	0.021547	Down	60
hsa-miR-4649-5p	−2.337674	0.022019	Down	61
hsa-miR-3622b-5p	−3.04368	0.022373	Down	62
hsa-miR-6840-3p	−6.817266	0.024616	Down	63
hsa-miR-4322	−6.233632	0.024852	Down	64
hsa-miR-574-5p	−5.490031	0.025207	Down	65
hsa-miR-4770	−4.247774	0.025561	Down	66
hsa-miR-513a-5p	−3.907964	0.025679	Down	67
hsa-miR-124-3p	−1.707013	0.025797	Down	68
hsa-miR-6819-5p	−2.385821	0.026151	Down	69
hsa-miR-339-3p	−5.134485	0.027332	Down	70
hsa-miR-26b-3p	−3.129563	0.02745	Down	71
hsa-miR-29c-5p	−7.931159	0.027922	Down	72
hsa-miR-29a-3p	−2.906434	0.02804	Down	73
hsa-miR-1227-5p	−2.287321	0.028276	Down	74
hsa-miR-4327	−2.710984	0.028512	Down	75
hsa-miR-99a-5p	−4.947917	0.02863	Down	76
hsa-miR-1296-5p	−9.401257	0.029103	Down	77
hsa-miR-378i	−4.649838	0.030283	Down	78
hsa-miR-6889-5p	−4.810854	0.030401	Down	79
hsa-miR-186-5p	−3.276383	0.031464	Down	80
hsa-miR-6824-5p	−8.197661	0.031936	Down	81
hsa-miR-195-3p	−4.796311	0.034416	Down	82
hsa-miR-3622a-5p	−4.145204	0.034888	Down	83
hsa-miR-5572	−6.053895	0.03536	Down	84
hsa-miR-6776-5p	−3.050977	0.035832	Down	85
hsa-miR-6790-5p	−2.868339	0.036895	Down	86
hsa-miR-6740-5p	−2.087867	0.037721	Down	87
hsa-miR-4269	−8.226931	0.038312	Down	88
hsa-miR-125b-5p	−2.694152	0.039138	Down	89
hsa-miR-3188	−8.008159	0.039256	Down	90
hsa-miR-6787-5p	−2.714687	0.03961	Down	91
hsa-miR-99b-5p	−1.811603	0.039847	Down	92
hsa-miR-30a-5p	−3.787576	0.040673	Down	93
hsa-miR-6765-5p	−2.365181	0.041027	Down	94
hsa-miR-1909-3p	−7.648533	0.041972	Down	95
hsa-miR-4507	−2.786848	0.042326	Down	96
hsa-miR-28-5p	−2.529154	0.042916	Down	97
hsa-miR-6892-5p	−2.081233	0.046458	Down	98
hsa-miR-4433b-3p	−1.923165	0.046694	Down	99
hsa-miR-6737-5p	−3.166103	0.04693	Down	100
hsa-miR-324-3p	−3.939764	0.048465	Down	101
hsa-miR-211-3p	−3.140159	0.048819	Down	102
hsa-miR-6798-5p	−2.080154	0.049174	Down	103
hsa-miR-4299	−4.93377	0.049882	Down	104

^aChanges of miRNA expression in MIBC compared with normal bladder.

^bRanking method is in descending order according to statistical significance (P-value) between the two groups. miRNA/miR, microRNA; MIBC, muscle invasive bladder cancer; Up, upregulated in MIBC; Down, downregulated in MIBC.