Table III.

The top 10 miRNAs with high degrees of miRNAs-gene-networks and miRNAs-GO-networks.

Rank	miRNAs	miRNA-gene-networks degreea	Featureb	miRNAs	miRNA-GO-networks degreea	Featureb
1	hsa-miR-497-5p	123	Down	hsa-miR-497-5p	637	Down
2	hsa-miR-29a-3p	88	Down	hsa-miR-29a-3p	518	Down
3	hsa-miR-124-3p	84	Down	hsa-miR-124-3p	516	Down
4	hsa-miR-4269	64	Down	hsa-miR-204-5p	494	Down
5	hsa-miR-145-5p	63	Down	hsa-miR-4269	458	Down
6	hsa-miR-204-5p	62	Down	hsa-miR-145-5p	430	Down
7	hsa-miR-4510	61	Down	hsa-miR-6840-3p	406	Down
8	hsa-miR-125b-5p	57	Down	hsa-miR-4510	404	Down
9	hsa-miR-6840-3p	50	Down	hsa-miR-6722-3p	387	Down
10	hsa-miR-6722-3p	47	Down	hsa-miR-1	383	Down

^aChanges of miRNA expression in MIBC compared with normal bladder.

^bTotal number of connections around the miRNA. miRNA/miR, microRNA; GO, gene ontology; Down, downregulated in muscle invasive bladder cancer.