Table V.
Top 10 TFs covering the majority of downstream DEGs in glaucoma.
| TF | Count | DEGs |
|---|---|---|
| Pax-4 | 50 | SERPING1, SV2A, EFHD1, NMI, DCLK1, CRELD1, CRELD1, AMIGO2, NBN, SERPING1, NBN, NBN, SLC12A2, NBN, FUT8, SELENBP1, SERPING1, SLC25A1, EFHD1, FUT8, LY96, EFHD1, HEPH, ID1, SERPING1, CYFIP2, UBR4, ABCA8, HDAC1, GEM, ID1, SELENBP1, PHKG2, SERPING1, EFHD1, CRELD1, CRELD1, ID1, LY96, SERPING1, ID1, LY96, HDAC1, EFHD1, SELENBP1, LY96, DMD, MID1, HDAC1 |
| 1-Oct | 44 | DMD, DMD, MID1, DMD, NBN, DMD, MID1, PDK1, BCKDHB, BCKDHB, NBN, DMD, BCKDHB, DMD, MID1, DMD, KCTD12, PLPP3, NMI, C1R, DMD, PBX1, SERPING1, DMD, UBR4, SERPING1, MID1, DCLK1, KCTD12, ABCA8, PDK1, SERPING1, DCLK1, PBX1, KCTD12, DMD, PHKG2, PBX1, NBN, BCKDHB, MID1, CASP1, NBN, DMD |
| Nkx2-5 | 38 | HEPH, NBN, SV2A, NBN, NBN, SERPING1, NBN, SERPING1, ABCA8, EFHD1, DMD, HEPH, SELENBP1, LY96, DCLK1, SELENBP1, PHKG2, SV2A, HDAC1, SLC12A2, BCKDHB, EFHD1, DMD, BNIP3, EFHD1, SERPING1, AMIGO2, RFTN1, SERPING1, ABCA8, ABCA8, SELENBP1, UBR4, EFHD1, LY96, KCTD12, ABCA8, KCTD12 |
| COMP1 | 26 | SLC12A2, MID1, MID1, SLC25A1, MID1, UBR4, DMD, PBX1, HEPH, FUT8, DMD, MID1, NBN, DMD, NBN, MID1, NBN, DCLK1, NBN, PHKG2, DMD, MID1, PBX1, SELENBP1, SLC25A1, DCLK1 |
| FOXD3 | 23 | DMD, DMD, SLC25A1, PBX1, PLPP3, SERPING1, PLPP3, DMD, DCLK1, DCLK1, SERPING1, PLPP3, DMD, PDK1, DMD, DMD, SERPING1, LY96, SLC25A1, CYFIP2, UBR4, DMD, PDK1 |
| HNF-1 | 23 | ABCA8, DMD, DMD, DMD, RFTN1, PHKG2, HEPH, DMD, SV2A, DMD, CYFIP2, DMD, AMIGO2, MID1, SELENBP1, FUT8, CASP1, NBN, NBN, KCTD12, DCLK1, DCLK1, DMD |
| HNF-4 | 20 | MID1, GEM, PDK1, BNIP3, BCKDHB, CYFIP2, SLC25A1, UBR4, MID1, SLC25A1, BNIP3, DMD, MID1, SLC25A1, KCTD12, CYFIP2, SLC12A2, PDK1, SLC25A1, CASP1 |
| Evi-1 | 18 | HDAC1, DMD, MID1, BCKDHB, FUT8, EFHD1, LY96, DMD, DMD, BCKDHB, DMD, MID1, PBX1, PBX1, SERPING1, SELENBP1, PHKG2, FUT8 |
| AP-1 | 15 | NBN, HEPH, HEPH, PHKG2, MID1, HDAC1, RFTN1, PHKG2, BCKDHB, DCLK1, CYFIP2, DCLK1, FUT8, PHKG2, BNIP3 |
| HNF-3β | 12 | PBX1, SERPING1, LY96, NMI, SELENBP1, DMD, SERPING1, DCLK1, ABCA8, DMD, CASP1, DMD |
TFs, transcription factor; DEGs, differentially expressed genes; PBX1, PBX homeobox 1; RFTN1, raftlin, lipid raft linker 1; ID1, inhibitor of differentiation 1.