Figure 2.
Histopathological analysis of the trabecular bone in the femoral head. At 2 weeks, the (A) control, (B) EPO, (C) control and (D) EPO groups. At 4 weeks, the (E) control and (F) EPO groups. At 6 weeks, the (G) control and (H) EPO groups. At 8 weeks, the (I) control and (J) EPO groups. Severely thinned and disordered trabeculae, large empty bone lacunae and numerous pyknotic nuclei of osteocytes were evident in femoral heads from the control group, whereas the morphological structure of EPO treatment group relatively improved (magnification, ×400). (I) Quantitative analysis of bone volume; and (J) empty lacunae rate in the control and EPO treatment group at 2, 4, 6 and 8 weeks. The BV/TV of femoral heads increased in the EPO treatment group at 6 and 8 weeks compared with the control group. The empty lacunae rate in femoral heads decreased in the EPO treatment group at 2 and 4 weeks compared with the control group. Data are presented as the mean ± standard deviation. *P<0.05 vs. the control group. EPO, erythropoietin; BV/TV, bone volume/total volume.