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. 2017 Oct 17;16(6):9347–9354. doi: 10.3892/mmr.2017.7795

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Copyright: © Cong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — 15-HPGD decreases PGE2 concentration. (A) Comparison of the concentration of PGE2 in SMSCs transfected with the wide type 15-HPGD coding sequence (pcDNA3.1-15-HPGD) or normal SMSCs (empty control vector). (B) mRNA expression of differentiation-associated genes and 15-HPGD in SMSCs transfected with the 15-HPGD coding sequence (pcDNA3.1-15-HPGD) or empty control vector SMSCs. *P<0.05 vs. Undifferentiated cells. PGE2, prostaglandin E2; 15-HPGD, 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; SMSCs, synovial mesenchymal stem cells; UTR, untranslated region; nom, normal; Sox9, transcription factor Sox9; AGN, aggrecan.