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miR-218 targets the 15-HPGD 3′-UTR. (A) The three point mutations induced in the 3′UTR of 15-HPGD. (B) Overexpression of exogenous miR-218 suppressed the 15-HPGD expression, with the opposite effect observed with mutant 15-HPGD. **P<0.01. miR, microRNA; 15-HPGD, 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; UTR, untranslated region; SMSCs, synovial mesenchymal stem cells; mut, mutant.
