Table II.

Effects of melatonin on migration in RKO cells.

	Half migration distance (mm)
Treatment group	Dose	24 h	48 h
Cells in media	–	20.379±0.855	27.551±0.273
DMSO	–	21.243±0.332	27.500±0.390
Melatonin	2.5 mM	16.104±0.546a	21.522±0.568a
H-1152	10 µM	10.482±0.844a	20.955±0.410a
Melatonin+	2.5 mM+	9.474±0.623a	17.534±0.453a
H-1152	10 µM

Data are presented as the mean ± standard deviation (n=5).

^aP<0.05 vs. DMSO. DMSO, dimethyl sulfoxide; H-1152, 5-[[(2s)-hexahydro-2-methyl-1H-1, 4-diazepin-1-yl] sulfonyl]-4-methyl-isoquinoline, dihydrochloride.