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. 2017 Sep 21;38(5):2667–2676. doi: 10.3892/or.2017.5982

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Copyright: © Liao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Downregulation of structure-specific recognition protein 1 (SSRP1) inhibits the proliferation in glioma cells. (A) The gene set enrichment analysis (GSEA) of GSE50161 revealed that SSRP1 may be involved in the progression of mRNA splicing, mRNA processing and the cell cycle. (B and C) The knockdown of SSRP1 by siRNA in U118 and U251 cells at both the mRNA and protein levels is shown. (D) Silencing of SSRP1 inhibited cell growth from day two as determined by CCK-8 assay in U118 and U251 cells. (E and F) EdU incorporation assay was performed to assess the DNA replication of U118 and U251 cells. Nuclei were stained with Hoechst (blue), and the proliferative cells were dyed red with EdU. A graphical representation of the percentage of EdU-positive cells is presented; *P<0.05, **P<0.01, ***P<0.001. Data is presented as the mean ± standard deviation (SD).