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. 2017 Sep 21;38(5):2667–2676. doi: 10.3892/or.2017.5982

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Copyright: © Liao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Structure-specific recognition protein 1 (SSRP1) regulates the expression of proliferation- and migration-associated genes in glioma via the MAPK pathway. (A and B) Knockdown of SSRP1 expression decreased the expression of proliferation-associated genes, including p65, c-myc, cyclin D and E. The expression of EGFR, VEGF and Snail, proteins involved in migration, were also suppressed. (C and D) The downregulated expression of SSRP1 significantly decreased the total and phosphorylated protein levels of p38 and ERK, and only the phosphorylated protein levels of JNK.