Table II.
Genes upregulated in SH-SY5Y cells treated with PF-3758309 compared with the DMSO control group.
| Gene | Description | +DMSO | +PF-3758309 | Fold change | P-value |
|---|---|---|---|---|---|
| NKX3 | Homeobox protein Nkx-3.1 | 0.001803 | 0.325538 | 180.5711 | 0.001869 |
| IFNA2 | Interferon α-2 | 1.410604 | 58.84984 | 41.71959 | 0.000504 |
| CD70 | CD70 antigen | 0.001643 | 0.050203 | 30.54704 | 0.000289 |
| BAD | Bcl2-associated agonist of cell death | 0.00431 | 0.10939 | 25.38147 | 0.040529 |
| EDA | Ectodysplasin-A | 0.931618 | 17.75593 | 19.05924 | 0.005116 |
| BIK | Bcl-2-interacting killer | 4.232982 | 67.26735 | 15.89124 | 0.005184 |
| BAK1 | Bcl-2 homologous antagonist/killer | 1.966254 | 29.21924 | 14.86036 | 0.063145 |
| MAPK8IP2 | JNK-interacting protein 2 | 3.721264 | 54.2914 | 14.5895 | 0.038288 |
| IFNB1 | Interferon β | 4.028926 | 41.34035 | 10.26089 | 0.001974 |
| CDKN1A | Cyclin-dependent kinase inhibitor 1 | 1573.162 | 9728.808 | 6.184238 | 0.002498 |
| LTB | Leukotriene B | 0.61312 | 3.435288 | 5.602959 | 0.002222 |
| TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein | 3.880523 | 20.69663 | 5.333463 | 0.002113 |
| EEF1A2 | Elongation factor 1-α 2 | 2374.489 | 11000.2 | 4.63266 | 1.53E-05 |
| BCL6 | B-cell lymphoma 6 protein | 3.452591 | 15.40138 | 4.460819 | 0.000277 |
| TBX3 | T-box transcription factor TBX3 | 3.061456 | 12.38112 | 4.044192 | 0.002894 |
| TP53I3 | Tumor protein p53-inducible protein 3 | 62.6146 | 240.1363 | 3.835148 | 0.013412 |
| TNFSF14 | Tumor necrosis factor ligand superfamily member 14 | 8.970259 | 32.94411 | 3.672593 | 0.029409 |
| BDNF | Brain-derived neurotrophic factor | 74.15095 | 271.9117 | 3.667002 | 0.019061 |
| CRYAB | α-crystallin B chain | 35.13305 | 122.0248 | 3.473218 | 9.65E-06 |
| PRKCZ | Protein kinase C zeta type | 10.70091 | 30.36617 | 2.83772 | 0.004804 |
| NOL3 | Nucleolar protein 3 | 1.524283 | 3.654028 | 2.397211 | 0.000416521 |
| TRAF6 | TNF receptor-associated factor 6 | 45.48575 | 97.24143 | 2.137844 | 0.026841067 |
| BCL2L2 | Bcl-2-like protein 2 | 16.04355 | 32.47326 | 2.024069 | 0.000458933 |