Table III.

Genes downregulated in SH-SY5Y cells treated with PF-3758309 compared with the DMSO control group.

Gene	Description	+DMSO	+PF-3758309	Fold change	P-value
TNFSF8	Tumor necrosis factor ligand superfamily member 8	6.279951	0.000828	0.000132	1.57936E-06
TNFSF18	Tumor necrosis factor ligand superfamily member 18	2.608747	0.003663	0.001404	3.6821E-05
TNFRSF10D	Tumor necrosis factor receptor superfamily member 10D	0.049302	0.000298	0.006039	0.042432232
CARD6	Caspase recruitment domain-containing protein 6	6.316158	0.096765	0.01532	0.006827195
Bcl2-A1	Bcl-2-related protein A1	709.7745	43.10898	0.060736	0.005756717
BCLAF1	Bcl-2-associated transcription factor 1	876.6456	66.62478	0.076	0.000645046
Bcl2L1	Bcl-2-like protein 1	110.9282	13.04641	0.117611	0.0297663
SOCS3	Suppressor of cytokine signaling 3	0.480132	0.060371	0.125739	0.000312779
BIRC3	Baculoviral IAP repeat-containing protein 3	1.289468	0.265287	0.205733	0.064433748
AZU1	Azurocidin	0.067689	0.015775	0.233046	0.03000673
CASP6	Caspase-6	9.207628	2.682053	0.291286	0.026410912
BCL3	B-cell lymphoma 3 protein	32.88351	10.42351	0.316983	0.02903268
NFKB1	Nuclear factor NF-κ-B p105 subunit	428.9497	141.1446	0.329047	1.91951E-07
CEBPB	CCAAT/enhancer-binding protein β	8624.573	2954.241	0.342538	0.003298518
AATF	Apoptosis-antagonizing transcription factor	243.7826	85.06575	0.348941	0.022581279
STAMBP	STAM-binding protein	12.88956	4.622598	0.358631	0.000569316
PIM2	Serine/threonine-protein kinase pim-2	405.8789	153.5832	0.378397	0.000267339
RIPK2	Receptor-interacting serine/threonine-protein kinase 2	1157.068	444.2396	0.383936	5.15526E-05
CASP1	Caspase-1	117.0643	45.73255	0.390662	0.013481275
IFI16	γ-interferon-inducible protein 16	1394.752	569.8934	0.408598	0.001865793