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. 2017 Sep 26;38(5):2752–2760. doi: 10.3892/or.2017.6001

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Copyright: © Feng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 9. — Inhibition of FOXQ1 reverses the promoting effects of miR-345 kncokdown on EMT, migration and invasion of MGC-803 cells. (A) FOXQ1 siRNA significantly decreased mRNA level of FOXQ1 in MGC-7901 cells transfected with miR-345 inhibitor, and subsequently led to increased mRNA level of E-cadherin and decreased mRNA level of N-cadherin, vimentin, Zeb2 and Snail1. (B) FOXQ1 siRNA significantly decreased the expression of FOXQ1 in MGC-7901 cells transfected with miR-345 inhibitor, and subsequently led to increased expression of E-cadherin and decreased expression of N-cadherin, vimentin, Zeb2 and Snail1. FOXQ1 knockdown abrogated the promoting effects of miR-345 knockdown on (C) migration and (D) invasion. *P<0.05. n=3. The error bars are SEM.