Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 30;38(5):2774–2786. doi: 10.3892/or.2017.5932

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Khurana et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 5. — Effect of Hsp90 inhibition or Nrf2-induction on AR-FL and AR-V7 protein levels in 22Rv1 cells. Cells were exposed to increasing concentrations of either (A) Ganetespib (G; 0–2000 nM) or (B) Bardoxolone methyl (BM; 0–1000 nM) and AR protein levels were measured. Top panels show representative immunoblots depicting AR-FL, AR-V7 and GAPDH levels. Bottom panels show fold change in AR proteins, normalized to GAPDH levels. (C) The effect of G or BM co-exposure with SFN on AR-FL and AR-V7 protein levels is shown. (D) The effect of combined treatment with G and BM on AR-FL and AR-V7 protein levels is shown. In both groups, top panels show representative immunoblots and bottom panels show normalized fold changes in AR proteins (n=2). Bar graphs show mean ± SEM and P-values (*P<0.05).