Table I.
Characterization of drug sensitivities with DOC-resistant A549 sublines by MTT assay.
| IC50 ± SDa (nmol/l) | |||
|---|---|---|---|
| Drug (nM) | A549 | A549/D16 | A549/D32 |
| Docetaxel | 7.6±1.8 (1.0) | 829.2±28.6 (109.1) | 2177.9±21.2 (286.5) |
| Vincristine | 20.0±2.2 (1.0) | 690.1±25.7 (34.5) | 811.0±27.4 (40.5) |
| Doxorubicin | 316.7±14.0 (1.0) | 3,468.3±29.1 (10.9) | 8,028.0±24.1 (25.3) |
| Pemetrexed | 1304.7±94.7 (1.0) | 187.7±2.5 (0.1) | 120.3±8.6 (0.1) |
| Methotrexate | 48.7±0.6 (1.0) | 87.0±1.7 (1.8) | 95.0±1.0 (2.0) |
a
Data are expressed as the mean ± SD of at least 3 independent experiments carried out in triplicate. DOC, docetaxel.